Science Has Always Been Marketed, From 18th-Century Coffeehouse Demos Of Newton’s Ideas To Today’s TikTok Explainers

People didn’t need to read Isaac Newton’s indecipherable Latin or understand his incomprehensible mathematics; they could just watch the live demonstrations, as in this depiction of an 18th-century nighttime scientific lecture on pneumatics. Joseph Wright of Derby/Science & Society Picture Library via Getty Images

BY BETH DEFAULT

ASSISTANT PROFESSOR OF MARKETING,

UNIVERSITY OF PORTLAND

People often see science as a world apart: cool, rational and untouched by persuasion or performance. In this view, scientists simply discover truth, and truth speaks for itself.

But history tells a different story. Scientific theories do not simply reveal themselves; they compete for attention, credibility and uptake. U.S. Supreme Court Justice Oliver Wendell Holmes Jr. once suggested that “the best test of truth is the power of the thought to get itself accepted in the competition of the market,” a line that helped popularize the metaphor of a “marketplace of ideas.”

In this view, science is not outside the market, but inside a public arena where claims vie for audiences, resources and belief – and where power, persuasion and social position shape which ideas are heard, trusted or forgotten.

As a marketing scholar trained in economic sociology, I study how institutions that are supposedly above or apart from market logics – such as science, religion, medicine and education – use marketing tools to sustain credibility and build or keep moral authority.

When I tell people that one of the areas I study is the marketing of science, they are often surprised at the concept. Yet persuasion is an integral part of the scientific process.

From Isaac Newton’s followers and their coffeehouse demonstrations of physics wonders to today’s TED Talks and TikTok explainers, scientists have long relied on storytelling and demonstration to make invisible truths visible. For scientific theories to supplant other plausible theories, to challenge existing theories and win acceptance, they must be correct – but they must also be convincing.

The original science influencers

In the early 1700s, Isaac Newton’s followers turned abstract theory into public performance and cultural fashion.

At the time, Cartesian philosophy dominated intellectual life. Newton’s 1687 book “Principia Mathematica” proposed a new worldview of gravity, optics and motion, but the mathematics was so dense that few could grasp it.

Although Newton himself was a recluse, a circle of zealous Newtonian men of science, described by historians as devoted disciples and even evangelists for Newton’s natural philosophy, took his new theories on the road. These itinerant lecturers performed experiments and spectaculars in London coffeehouses and aristocratic salons, demonstrating Newtonian physics. They sold tickets, pamphlets and even branded scientific instruments so audiences could reproduce these marvels at home.

Historian of science Jeff Wigelsworth showed that Newton’s evangelizers built what today might be called a brand: experiences, artifacts and emotions that linked scientific authority to Enlightenment ideals of reason and progress, and to their own personalities.

My own research finds that these men of science also used a suite of early marketing activities. Besides developing products to sell to promote Newtonian science, they came up with promotions that targeted different audiences, adjusted their pricing and used varied distribution strategies.

Along with their pure entertainment value, these public demonstrations were integrally entwined with Newtonian scientific viewpoints and helped these ideas gain popularity and legitimacy in public life.

As in our own time, where one’s stance on various scientific debates often signals one’s political ideology or religious beliefs, aligning in support of Newton’s theories over, say, René Descartes’ or Gottfried Wilhelm Liebniz’s in discussion and by practice also came to indicate a certain stance on theology and politics, and to be Newtonian became a social signal of a desirable style and social status.

From coffeehouses to TikTok

Three centuries later, the marketing of science is more visible, and more complicated, than ever.

Scientists can now promote their work on social media platforms like Bluesky, YouTube and TikTok, crafting personal brands and cultivating audiences. Influencer-scientists use storytelling, humor and design to reach millions. If scientists don’t do this themselves, their proponents, just like Newton’s disciples, may do it for them.

I call this process the marketization of moral authority: when historically sacred or ostensibly impartial institutions such as science, religion and education increasingly organize themselves as markets, adopting promotional, pricing and product logics to secure their legitimacy, authority, appeal and funding.

None of this effort is inherently bad. As in Newton’s time, effective marketing communications can make complex work accessible and even inspiring. It can publicize and defend important theoretical and practical findings in a competitive, skeptical world.

But it raises questions.

Value of recognizing that science gets marketed

You might wonder why anyone beyond academia should care whether science is marketed. After all, every field uses communication and outreach.

It matters because science is one of the few institutions people still rely on to anchor truth claims in evidence. And when the boundary between scientific fact and promotion blurs, it becomes easy to confuse confidence with credibility, or charisma with responsible consensus.

Scientific rhetoric can easily be co-opted. Think of wellness influencers using “quantum” jargon to sell supplements; AI companies invoking neuroscience to legitimatize untested technologies; charlatans mimicking the language of peer review to sow doubt.

But awareness is a form of protection. When you recognize that scientific authority can be built through persuasion, you become more discerning consumers of it. Faced with a message involving science, you can consider:

Who is framing this message, and why?

What evidence supports it? Is this evidence vetted and validated by rigorous studies?

Is it appealing to emotion or identity, rather than objective logic?

This process can help you become more scientifically literate.

Science has never been the pristine, market-free ideal many imagine. It has always lived – sometimes uneasily – within a marketplace of ideas, competing for belief, attention and authority.

Recognizing that reality humanizes science and reminds us that truth must be discovered, communicated and, ultimately, accepted.

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Even Short Trips To Space Can Change An Astronaut’s Biology − A New Set Of Studies Offers The Most Comprehensive Look At Spaceflight Health Since NASA’s Twins Study

BY SUSAN BAILEY

PROFESSOR OF RADIATION CANCER,

BIOLOGY AND ONCOLOGY,

COLORADO STATE UNIVERSITY

Only about 600 people have ever traveled to space. The vast majority of astronauts over the past six decades have been middle-aged men on short-duration missions of fewer than 20 days.

Today, with private, commercial and multinational spaceflight providers and flyers entering the market, we are witnessing a new era of human spaceflight. Missions have ranged from minutes, hours and days to months.

As humanity looks ahead to returning to the Moon over the coming decade, space exploration missions will be much longer, with many more space travelers and even space tourists. This also means that a wider diversity of people will experience the extreme environment of space – more women and people of different ethnicities, ages and health status.

Since people respond differently to the unique stressors and exposures of space, researchers in space health, like me, seek to better understand the human health effects of spaceflight. With such information, we can figure out how to help astronauts stay healthy both while they’re in space and once they return to Earth.

As part of the historic NASA Twins Study, in 2019, my colleagues and I published groundbreaking research on how one year on board the International Space Station affects the human body.

I am a radiation cancer biologist in Colorado State University’s Department of Environmental and Radiological Health Sciences. I’ve spent the past few years continuing to build on that earlier research in a series of papers recently published across the portfolio of Nature journals.

These papers are part of the Space Omics and Medical Atlas package of manuscripts, data, protocols and repositories that represent the largest collection ever assembled for aerospace medicine and space biology. Over 100 institutions from 25 countries contributed to the coordinated release of a wide range of spaceflight data.

The NASA Twins Study

NASA’s Twins Study seized on a unique research opportunity.

NASA selected astronaut Scott Kelly for the agency’s first one-year mission, during which he spent a year on board the International Space Station from 2015 into 2016. Over the same time period, his identical twin brother, Mark Kelly, a former astronaut and current U.S. senator representing Arizona, remained on Earth.

My team and I examined blood samples collected from the twin in space and his genetically matched twin back on Earth before, during and after spaceflight. We found that Scott’s telomeres – the protective caps at the ends of chromosomes, much like the plastic tip that keeps a shoelace from fraying – lengthened, quite unexpectedly, during his year in space.

When Scott returned to Earth, however, his telomeres quickly shortened. Over the following months, his telomeres recovered but were still shorter after his journey than they had been before he went to space.

As you get older, your telomeres shorten because of a variety of factors, including stress. The length of your telomeres can serve as a biological indicator of your risk for developing age-related conditions such as dementia, cardiovascular disease and cancer.

In a separate study, my team studied a cohort of 10 astronauts on six-month missions on board the International Space Station. We also had a control group of age- and sex-matched participants who stayed on the ground.

We measured telomere length before, during and after spaceflight and again found that telomeres were longer during spaceflight and then shortened upon return to Earth. Overall, the astronauts had many more short telomeres after spaceflight than they had before.

One of the other Twins Study investigators, Christopher Mason, and I conducted another telomere study – this time with twin high-altitude mountain climbers – a somewhat similar extreme environment on Earth.

We found that while climbing Mount Everest, the climbers’ telomeres were longer, and after they descended, their telomeres shortened. Their twins who remained at low altitude didn’t experience the same changes in telomere length. These results indicate that it’s not the space station’s microgravity that led to the telomere length changes we observed in the astronauts – other culprits, such as increased radiation exposure, are more likely.

Civilians in space

In our latest study, we studied telomeres from the crew on board SpaceX’s 2021 Inspiration4 mission. This mission had the first all-civilian crew, whose ages spanned four decades. All of the crew members’ telomeres lengthened during the mission, and three of the four astronauts also exhibited telomere shortening once they were back on Earth.

What’s particularly interesting about these findings is that the Inspiration4 mission lasted only three days. So, not only do scientists now have consistent and reproducible data on telomeres’ response to spaceflight, but we also know it happens quickly. These results suggest that even short trips, like a weekend getaway to space, will be associated with changes in telomere length.

Scientists still don’t totally understand the health impacts of such changes in telomere length. We’ll need more research to figure out how both long and short telomeres might affect an astronaut’s long-term health.

Telomeric RNA

In another paper, we showed that the Inspiration4 crew – as well as Scott Kelly and the high-altitude mountain climbers – exhibited increased levels of telomeric RNA, termed TERRA.

Telomeres consist of lots of repetitive DNA sequences. These are transcribed into TERRA, which contributes to telomere structure and helps them do their job.

Together with laboratory studies, these findings tell us that telomeres are being damaged during spaceflight. While there is still a lot we don’t know, we do know that telomeres are especially sensitive to oxidative stress. So, the chronic oxidative damage that astronauts experience when exposed to space radiation around the clock likely contributes to the telomeric responses we observe.

We also wrote a review article with a more futuristic perspective of how better understanding telomeres and aging might begin to inform the ability of humans to not only survive long-duration space travel but also to thrive and even colonize other planets. Doing so would require humans to reproduce in space and future generations to grow up in space. We don’t know if that’s even possible – yet.

Plant telomeres in space

My colleagues and I contributed other work to the Space Omics and Medical Atlas package, as well, including a paper published in Nature Communications. The study team, led by Texas A&M biologist Dorothy Shippen and Ohio University biologist Sarah Wyatt, found that, unlike people, plants flown in space did not have longer telomeres during their time on board the International Space Station.

The plants did, however, ramp up their production of telomerase, the enzyme that helps maintain telomere length.

As anyone who’s seen “The Martian” knows, plants will play an essential role in long-term human survival in space. This finding suggests that plants are perhaps more naturally suited to withstand the stressors of space than humans.

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A Brain Pacemaker Helped A Woman With Crippling Depression. It May Soon Be Available To More People

Emily Hollenbeck, a deep brain stimulation therapy patient, demonstrates an EEG device that records brain activity as she reacts to short videos at Mt Sinai's "Q-Lab" in New York on Dec. 20, 2023. (AP Photo/Mary Conlon)

BY LAURA UNGAR

NEW YORK (AP) — Emily Hollenbeck lived with a deep, recurring depression she likened to a black hole, where gravity felt so strong and her limbs so heavy she could barely move. She knew the illness could kill her. Both of her parents had taken their lives.

She was willing to try something extreme: Having electrodes implanted in her brain as part of an experimental therapy.

Researchers say the treatment —- called deep brain stimulation, or DBS — could eventually help many of the nearly 3 million Americans like her with depression that resists other treatments. It’s approved for conditions such as Parkinson’s disease and epilepsy, and many doctors and patients hope it will become more widely available for depression soon.

The treatment gives patients targeted electrical impulses, much like a pacemaker for the brain. A growing body of recent research is promising, with more underway — although two large studies that showed no advantage to using DBS for depression temporarily halted progress, and some scientists continue to raise concerns.

Meanwhile, the Food and Drug Administration has agreed to speed up its review of Abbott Laboratories’ request to use its DBS devices for treatment-resistant depression.

“At first I was blown away because the concept of it seems so intense. Like, it’s brain surgery. You have wires embedded in your brain,” said Hollenbeck, who is part of ongoing research at Mount Sinai West. “But I also felt like at that point I tried everything, and I was desperate for an answer.”

“NOTHING ELSE WAS WORKING”

Hollenbeck suffered from depression symptoms as a child growing up in poverty and occasional homelessness. But her first major bout happened in college, after her father’s suicide in 2009. Another hit during a Teach for America stint, leaving her almost immobilized and worried she’d lose her classroom job and sink into poverty again. She landed in the hospital.

“I ended up having sort of an on-and-off pattern,” she said. After responding to medication for a while, she’d relapse.

She managed to earn a doctorate in psychology, even after losing her mom in her last year of grad school. But the black hole always returned to pull her in. At times, she said, she thought about ending her life.

She said she’d exhausted all options, including electroconvulsive therapy, when a doctor told her about DBS three years ago.

“Nothing else was working,” she said.

She became one of only a few hundred treated with DBS for depression.

Hollenbeck had the brain surgery while sedated but awake. Dr. Brian Kopell, who directs Mount Sinai’s Center for Neuromodulation, placed thin metal electrodes in a region of her brain called the subcallosal cingulate cortex, which regulates emotional behavior and is involved in feelings of sadness.

The electrodes are connected by an internal wire to a device placed under the skin in her chest, which controls the amount of electrical stimulation and delivers constant low-voltage pulses. Hollenbeck calls it “continuous Prozac.”

Doctors say the stimulation helps because electricity speaks the brain’s language. Neurons communicate using electrical and chemical signals.

In normal brains, Kopell said, electrical activity reverberates unimpeded in all areas, in a sort of dance. In depression, the dancers get stuck within the brain’s emotional circuitry. DBS seems to “unstick the circuit,” he said, allowing the brain to do what it normally would.

Hollenbeck said the effect was almost immediate.

“The first day after surgery, she started feeling a lifting of that negative mood, of the heaviness,” said her psychiatrist, Dr. Martijn Figee. “I remember her telling me that she was able to enjoy Vietnamese takeout for the first time in years and really taste the food. She started to decorate her home, which had been completely empty since she moved to New York.”

For Hollenbeck, the most profound change was finding pleasure in music again.

“When I was depressed, I couldn’t listen to music. It sounded and felt like I was listening to radio static,” she said. “Then on a sunny day in the summer, I was walking down the street listening to a song. I just felt this buoyancy, this, ‘Oh, I want to walk more, I want to go and do things!’ And I realized I’m getting better.”

She only wishes the therapy had been there for her parents.

THE TREATMENT’S HISTORY

The road to this treatment stretches back two decades, when neurologist Dr. Helen Mayberg led promising early research.

But setbacks followed. Large studies launched more than a dozen years ago showed no significant difference in response rates for treated and untreated groups. Dr. Katherine Scangos, a psychiatrist at the University of California, San Francisco, also researching DBS and depression, cited a couple of reasons: The treatment wasn’t personalized, and researchers looked at outcomes over a matter of weeks.

Some later research showed depression patients had stable, long-term relief from DBS when observed over years. Overall, across different brain targets, DBS for depression is associated with average response rates of 60%, one 2022 study said.

Treatments being tested by various teams are much more tailored to individuals today. Mount Sinai’s team is one of the most prominent researching DBS for depression in the U.S. There, a neuroimaging expert uses brain images to locate the exact spot for Kopell to place electrodes.

“We have a template, a blueprint of exactly where we’re going to go,” said Mayberg, a pioneer in DBS research and founding director of The Nash Family Center for Advanced Circuit Therapeutics at Mount Sinai. “Everybody’s brain is a little different, just like people’s eyes are a little further apart or a nose is a little bigger or smaller.”

Other research teams also tailor treatment to patients, although their methods are slightly different. Scangos and her colleagues are studying various targets in the brain and delivering stimulation only when needed for severe symptoms. She said the best therapy may end up being a combination of approaches.

As teams keep working, Abbott is launching a big clinical trial this year, ahead of a potential FDA decision.

“The field is advancing quite quickly,” Scangos said. “I’m hoping we will have approval within a short time.”

But some doctors are skeptical, pointing to potential complications such as bleeding, stroke or infection after surgery.

Dr. Stanley Caroff, an emeritus professor of psychiatry at the University of Pennsylvania, said scientists still don’t know the exact pathways or mechanisms in the brain that produce depression, which is why it’s hard to pick a site to stimulate. It’s also tough to select the right patients for DBS, he said, and approved, successful treatments for depression are available.

“I believe from a psychiatric point of view, the science is not there,” he said of DBS for depression.

MOVING FORWARD

Hollenbeck acknowledges DBS hasn’t been a cure-all; she still takes medicines for depression and needs ongoing care.

She recently visited Mayberg in her office and discussed recovery. “It’s not about being happy all the time,” the doctor told her. “It’s about making progress.”

That’s what researchers are studying now — how to track progress.

Recent research by Mayberg and others in the journal Nature showed it’s possible to provide a “readout” of how someone is doing at any given time. Analyzing the brain activity of DBS patients, researchers found a unique pattern that reflects the recovery process. This gives them an objective way to observe how people get better and distinguish between impending depression and typical mood fluctuations.

Scientists are confirming those findings using newer DBS devices in a group of patients that includes Hollenbeck.

She and other participants do their part largely at home. She gives researchers regular brain recordings by logging onto a tablet, putting a remote above the pacemaker-like device in her chest and sending the data. She answers questions that pop up about how she feels. Then she records a video that will be analyzed for things such as facial expression and speech.

Occasionally, she goes into Mount Sinai’s “Q-Lab,” an immersive environment where scientists do quantitative research collecting all sorts of data, including how she moves in a virtual forest or makes circles in the air with her arms. Like many other patients, she moves her arms faster now that she’s doing better.

Data from recordings and visits are combined with other information, such as life events, to chart how she’s doing. This helps guide doctors’ decisions, such as whether to increase her dose of electricity – which they did once.

On a recent morning, Hollenbeck moved her collar and brushed her hair aside to reveal scars on her chest and head from her DBS surgery. To her, they’re signs of how far she’s come.

She makes her way around the city, taking walks in the park and going to libraries, which were a refuge in childhood. She no longer worries that normal life challenges will trigger a crushing depression.

“The stress is pretty extreme at times, but I’m able to see and remember, even on a bodily level, that I’m going to be OK,” she said.

“If I hadn’t had DBS, I’m pretty sure I would not be alive today.”
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

Quantum Dots Are Part Of A Revolution In Engineering Atoms In Useful Ways – Nobel Prize For Chemistry Recognizes The Power Of Nanotechnology

THE CONVERSATION

Quantum dots are now a normal part of many consumer items, including televisions. Soeren Stache/picture alliance via Getty Images

BY ANDREW MAYNARD

PROFESSOR OF ADVANCED TECHNOLOGY TRANSITIONS

ARIZONA STATE UN IVERSITY

The 2023 Nobel Prize for chemistry isn’t the first Nobel awarded for research in nanotechnology. But it is perhaps the most colorful application of the technology to be associated with the accolade.

This year’s prize recognizes Moungi Bawendi, Louis Brus and Alexei Ekimov for the discovery and development of quantum dots. For many years, these precisely constructed nanometer-sized particles – just a few hundred thousandths the width of a human hair in diameter – were the darlings of nanotechnology pitches and presentations. As a researcher and adviser on nanotechnology, I’ve even used them myself when talking with developers, policymakers, advocacy groups and others about the promise and perils of the technology.

The origins of nanotechnology predate Bawendi, Brus and Ekimov’s work on quantum dots – the physicist Richard Feynman speculated on what could be possible through nanoscale engineering as early as 1959, and engineers like Erik Drexler were speculating about the possibilities of atomically precise manufacturing in the the 1980s. However, this year’s trio of Nobel laureates were part of the earliest wave of modern nanotechnology where researchers began putting breakthroughs in material science to practical use.

Quantum dots brilliantly fluoresce: They absorb one color of light and reemit it nearly instantaneously as another color. A vial of quantum dots, when illuminated with broad spectrum light, shines with a single vivid color. What makes them special, though, is that their color is determined by how large or small they are. Make them small and you get an intense blue. Make them larger, though still nanoscale, and the color shifts to red.

This property has led to many arresting images of rows of vials containing quantum dots of different sizes going from a striking blue on one end, through greens and oranges, to a vibrant red at the other. So eye-catching is this demonstration of the power of nanotechnology that, in the early 2000s, quantum dots became iconic of the strangeness and novelty of nanotechnology.

But, of course, quantum dots are more than a visually attractive parlor trick. They demonstrate that unique, controllable and useful interactions between matter and light can be achieved through engineering the physical form of matter – modifying the size, shape and structure of objects or instance – rather than playing with the chemical bonds between atoms and molecules. The distinction is an important one, and it’s at the heart of modern nanotechnology.

Skip chemical bonds, rely on quantum physics

The wavelengths of light that a material absorbs, reflects or emits are usually determined by the chemical bonds that bind its constituent atoms together. Play with the chemistry of a material and it’s possible to fine-tune these bonds so that they give you the colors you want. For instance, some of the earliest dyes started with a clear substance such as analine, transformed through chemical reactions to the desired hue.

It’s an effective way to work with light and color, but it also leads to products that fade over time as those bonds degrade. It also frequently involves using chemicals that are harmful to humans and the environment.

Quantum dots work differently. Rather than depending on chemical bonds to determine the wavelengths of light they absorb and emit, they rely on very small clusters of semiconducting materials. It’s the quantum physics of these clusters that then determines what wavelengths of light are emitted – and this in turn depends on how large or small the clusters are.

This ability to tune how a material behaves by simply changing its size is a game changer when it comes to the intensity and quality of light that quantum dots can produce, as well as their resistance to bleaching or fading, their novel uses and – if engineered smartly – their toxicity.

Of course, few materials are completely nontoxic, and quantum dots are no exception. Early quantum dots were often based on cadmium selenide for instance – the component materials of which are toxic. However, the potential toxicity of quantum dots needs to be balanced by the likelihood of release and exposure and how they compare with alternatives.

Since its earlier days, quantum dot technology has evolved in safety and usefulness and has found its way into an increasing number of products, from displays and lighting, to sensors, biomedical applications and more. In the process, some of their novelty has perhaps worn off. It can be hard to remember just how much of a quantum leap the technology is that’s being used to promote the latest generation of flashy TVs, for instance.

And yet, quantum dots are a pivotal part of a technology transition that’s revolutionizing how people work with atoms and molecules.

‘Base coding’ on an atomic level

In my book “Films from the Future: the Technology and Morality of Sci-Fi Movies,” I write about the concept of “base coding.” The idea is simple: If people can manipulate the most basic code that defines the world we live in, we can begin to redesign and reengineer it.

This concept is intuitive when it comes to computing, where programmers use the “base code” of 1,s and 0’s, albeit through higher level languages. It also makes sense in biology, where scientists are becoming increasingly adept at reading and writing the base code of DNA and RNA – in this case, using the chemical bases adenine, guanine, cytosine and thymine as their coding language.

This ability to work with base codes also extends to the material world. Here, the code is made up of atoms and molecules and how they are arranged in ways that lead to novel properties.

Bawendi, Brus and Ekimov’s work on quantum dots is a perfect example of this form of material-world base coding. By precisely forming small clusters of particular atoms into spherical “dots,” they were able to tap into novel quantum properties that would otherwise be inaccessible. Through their work they demonstrated the transformative power that comes through coding with atoms.

They paved the way for increasingly sophisticated nanoscale base coding that is now leading to products and applications that would not be possible without it. And they were part of the inspiration for a nanotechnology revolution that is continuing to this day. Reengineering the material world in these novel ways far transcends what can be achieved through more conventional technologies.

This possibility was captured in a 1999 U.S. National Science and Technology Council report with the title Nanotechnology: Shaping the World Atom by Atom. While it doesn’t explicitly mention quantum dots – an omission that I’m sure the authors are now kicking themselves over – it did capture just how transformative the ability to engineer materials at the atomic scale could be.

This atomic-level shaping of the world is exactly what Bawendi, Brus and Ekimov aspired to through their groundbreaking work. They were some of the first materials “base coders” as they used atomically precise engineering to harness the quantum physics of small particles – and the Nobel committee’s recognition of the significance of this is well deserved.

You shed DNA everywhere you go – trace samples in the water, sand and air are enough to identify who you are, raising ethical questions about privacy

BY JENNY WHILDE AND JESSICA ALICE FARRELL

UNIVERSITY OF FLORIDA

Human DNA can be sequenced from small amounts of water, sand and air in the environment to potentially extract identifiable information like genetic lineage, gender, and health risks, according to our new research.

Every cell of the body contains DNA. Because each person has a unique genetic code, DNA can be used to identify individual people. Typically, medical practitioners and researchers obtain human DNA through direct sampling, such as blood tests, swabs or biopsies. However, all living things, including animals, plants and microbes, constantly shed DNA. The water, soil and even the air contain microscopic particles of biological material from living organisms.

DNA that an organism has shed into the environment is known as environmental DNA, or eDNA. For the last couple of decades, scientists have been able to collect and sequence eDNA from soil or water samples to monitor biodiversity, wildlife populations and disease-causing pathogens. Tracking rare or elusive endangered species through their eDNA has been a boon to researchers, since traditional monitoring methods such as observation or trapping can be difficult, often unsuccessful and intrusive to the species of interest.

Researchers using eDNA tools usually focus only on the species they’re studying and disregard DNA from other species. However, humans also shed, cough and flush DNA into their surrounding environment. And as our team of geneticists, ecologists and marine biologists in the Duffy Lab at the University of Florida found, signs of human life can be found everywhere but in the most isolated locations.

Animals, humans and viruses in eDNA

Our team uses environmental DNA to study endangered sea turtles and the viral tumors to which they are susceptible. Tiny hatchling sea turtles shed DNA as they crawl along the beach on their way to the ocean shortly after they are born. Sand scooped from their tracks contains enough DNA to provide valuable insights into the turtles and the chelonid herpesviruses and fibropapillomatosis tumors that afflict them. Scooping a liter of water from the tank of a recovering sea turtle under veterinary care equally provides a wealth of genetic information for research. Unlike blood or skin sampling, collecting eDNA causes no stress to the animal.

Genetic sequencing technology used to decode DNA has improved rapidly in recent years, and it is now possible to easily sequence the DNA of every organism in a sample from the environment. Our team suspected that the sand and water samples we were using to study sea turtles would also contain DNA from a number of other species – including, of course, humans. What we didn’t know was just how informative the human DNA we could extract would be.

To figure this out, we took samples from a variety of locations in Florida, including the ocean and rivers in urban and rural areas, sand from isolated beaches and a remote island never usually visited by people. We found human DNA in all of those locations except the remote island, and these samples were high quality enough for analysis and sequencing.

We also tested the technique in Ireland, tracing along a river that winds from a remote mountaintop, through small rural villages and into the sea at a larger town of 13,000 inhabitants. We found human DNA everywhere but in the remote mountain tributary where the river starts, far from human habitation.

We also collected air samples from a room in our wildlife veterinary hospital in Florida. People who were present in the room gave us permission to take samples from the air. We recovered DNA matching the people, the animal patient and common animal viruses present at the time of collection.

Surprisingly, the human eDNA found in the local environment was intact enough for us to identify mutations associated with disease and to determine the genetic ancestry of people who live in the area. Sequencing DNA that volunteers left in their footprints in the sand even yielded part of their sex chromosomes.

Ethical implications of collecting human eDNA

Our team dubs inadvertent retrieval of human DNA from environmental samples “human genetic bycatch.” We’re calling for deeper discussion about how to ethically handle human environmental DNA.

Human eDNA could present significant advances to research in fields as diverse as conservation, epidemiology, forensics and farming. If handled correctly, human eDNA could help archaeologists track down undiscovered ancient human settlements, allow biologists to monitor cancer mutations in a given population or provide law enforcement agencies useful forensic information.

However, there are also myriad ethical implications relating to the inadvertent or deliberate collection and analysis of human genetic bycatch. Identifiable information can be extracted from eDNA, and accessing this level of detail about individuals or populations comes with responsibilities relating to consent and confidentiality.

While we conducted our study with the approval of our institutional review board, which ensures that studies on people adhere to ethical research guidelines, there is no guarantee that everyone will treat this type of information ethically.

Many questions arise regarding human environmental DNA. For instance, who should have access to human eDNA sequences? Should this information be made publicly available? Should consent be required before taking human eDNA samples, and from whom? Should researchers remove human genetic information from samples originally collected to identify other species?

We believe it is vital to implement regulations that ensure collection, analysis and data storage are carried out ethically and appropriately. Policymakers, scientific communities and other stakeholders need to take human eDNA collection seriously and balance consent and privacy against the possible benefits of studying eDNA. Raising these questions now can help ensure everyone is aware of the capabilities of eDNA and provide more time to develop protocols and regulations to ensure appropriate use of eDNA techniques and the ethical handling of human genetic bycatch.

Raw Materials, Or Sacred Beings? Lithium Extraction Puts Two Worldviews Into Tension

Illustration: Geo Energy

BY MARIO OROSPE HERNANDEZ, ARIZONA STATE UNIVERSITY

Located in the heart of South America, Bolivia contains the largest lithium deposits in the world – an enviable position, in many countries’ eyes, as the market for electric vehicles takes off. Though EVs emit fewer greenhouse gases than fuel-powered vehicles, their batteries require more minerals – especially lithium, which is also used to make batteries for smartphones and computers.

Unlike its neighbors Chile and Argentina, Bolivia has yet to become a major player in the global lithium market. In part, this is because its high-altitude salt flats aren’t suited to the usual extraction method, solar evaporation.

But that looks poised to change: In January 2023, state company YLB signed an agreement with the Chinese consortium CBC, which includes the world’s largest producer of lithium-ion batteries, to introduce a new method called direct lithium extraction.

It may prove an economic boon. But since colonial times, the legacy of mineral abundance in Bolivia has also been one of pollution, poverty and exploitation. While some residents are hopeful about the potential benefits of the growing lithium industry, others are concerned about extraction’s local impact. In particular, direct lithium extraction demands a great deal of fresh water, potentially endangering surrounding ecosystems as has happened in other parts of South America’s “lithium triangle.”

A rapid escalation of lithium extraction in the Bolivian Andes also represents a looming clash between two fundamentally different views of nature: modern industrial society’s and that of the Indigenous communities who call the region home – a focus of my current research collaborations and dissertation project.

The Pachamama

Bolivia is home to 36 ethnic groups across its highland and lowland regions. Aymara and Quechua peoples comprise most of the Indigenous communities in the Andes Mountains.

For these cultures, nature is not a means to human ends. Instead, it is seen as a group of beings with personhood, history and power beyond human reach. For example, the female divinity of fertility, to whom people owe respect, is the Pachamama. Since she sustains and secures the reproduction of life, Andean Indigenous people make offerings to the Pachamama in ancestral rituals known as “challas” that seek to reinforce their connection with her.

Similarly, highland groups recognize mountains not as a set of inert rocks, but as ancestral guardians called “Achachilas” in Aymara and “Apus” in Quechua. Each Andean community praises a nearby mountain whom they believe protects and oversees their lives.

In Uyuni, for example, where one of the two new lithium plants will be constructed, Indigenous communities acknowledge the presence of these sacred beings. To this day, worshipers in nearby Lipez region explain the salt flat’s origin with a traditional legend: It is the mother’s milk of their Apu, a female volcano named Tunupa.

However, religious concepts such as “sacred” or “divine” do not necessarily capture the relationships that Andean Indigenous people have long established with these more-than-human beings, who have been known since pre-colonial times as “huacas.” These entities are not considered “gods,” or thought of as dealing with otherworldly beliefs. Rather, they are treated as integral to people’s earthly everyday life.

For instance, before meals, Quechua and Aymara peoples throw coca leaves or spill their drinks on the ground to share their food with these beings as a sign of gratitude and reciprocity.

Lifeless matter

In industrial societies, on the other hand, nature is understood as something external to humanity – an object that can be mastered through science and technology. The modern economy turns nature into a source of raw materials: morally and spiritually inert matter that is there to be extracted and mobilized worldwide. Within this framework, a mineral like lithium is a resource to be developed in the pursuit of economic gains for human beings.

In fact, the history of these competing notions is deeply entwined with the history of the colonial era, as different cultures came into violent conflict. As the Spanish discovered the mineral bounty of the so-called New World, like gold and silver, they began an intensive extraction of its riches, relying on forced labor from local people and imported slaves.

The concept of “raw materials” can be traced to the theological notion of “prime matter.” The term originally comes from Aristotle, whose work was introduced to Christianity via Latin translations around the 12th century. In the way Christians adapted his idea of prime matter, everything was ordered by its level of “perfection,” ranging from the lowest level – prime matter, the most basic “stuff” of the world – to rocks, plants, animals, humans, angels and, finally, God.

The Catholic Church and the Spanish Empire later used this medieval understanding of matter as something passive, without spirit, to justify the extraction of resources during colonial times. The closer things were to prime matter, their argument supposed, the more they needed human imprint and an external purpose to make them valuable.

This notion was also used by Christian colonizers who were intent on destroying traditions that they saw as idolatrous. In their eyes, reverence toward a mountain or the earth itself was worshiping a mere “thing,” a false god. The church and the empire believed it was critical to desacralize these more-than-human beings and treat them as mere resources.

This flattened vision of nature served as the basis for the modern economic concept of raw materials, which was introduced in the 18th century with the birth of economics as a social science.

The road ahead

Bolivia’s lithium projects pose a new potential clash of worldviews. However, extraction initiatives have faced severe setbacks in the last few years, including social protests, the 2019 political crisis and a lack of necessary technology. The Chinese deal represents a new milestone, yet its outcomes are still uncertain: for the economy, for local communities and for the Earth.

Today, electric vehicles are widely considered part of the solution to the climate crisis. Yet they will necessitate a mining surge to meet their battery demands. If societies really want a greener future, technological shifts such as EVs will be just part of the answer, alongside other changes like more sustainable urban planning and improved public transportation.

But in addition, perhaps other cultures could learn from Andean relations with nature as more-than-human beings: an inspiration to rethink development and turn our own way of living into something less destructive.

Imagination Makes Us Human – This Unique Ability To Envision What Doesn’t Exist Has A Long Evolutionary History

BY ANDREY VYSHEDSKIY

You can easily picture yourself riding a bicycle across the sky even though that’s not something that can actually happen. You can envision yourself doing something you’ve never done before – like water skiing – and maybe even imagine a better way to do it than anyone else.

Imagination involves creating a mental image of something that is not present for your senses to detect, or even something that isn’t out there in reality somewhere. Imagination is one of the key abilities that make us human. But where did it come from?

I’m a neuroscientist who studies how children acquire imagination. I’m especially interested in the neurological mechanisms of imagination. Once we identify what brain structures and connections are necessary to mentally construct new objects and scenes, scientists like me can look back over the course of evolution to see when these brain areas emerged – and potentially gave birth to the first kinds of imagination.

From bacteria to mammals

After life emerged on Earth around 3.4 billion years ago, organisms gradually became more complex. Around 700 million years ago, neurons organized into simple neural nets that then evolved into the brain and spinal cord around 525 million years ago.

Eventually dinosaurs evolved around 240 million years ago, with mammals emerging a few million years later. While they shared the landscape, dinosaurs were very good at catching and eating small, furry mammals. Dinosaurs were cold-blooded, though, and, like modern cold-blooded reptiles, could only move and hunt effectively during the daytime when it was warm. To avoid predation by dinosaurs, mammals stumbled upon a solution: hide underground during the daytime.

Not much food, though, grows underground. To eat, mammals had to travel above the ground – but the safest time to forage was at night, when dinosaurs were less of a threat. Evolving to be warm-blooded meant mammals could move at night. That solution came with a trade-off, though: Mammals had to eat a lot more food than dinosaurs per unit of weight in order to maintain their high metabolism and to support their constant inner body temperature around 99 degrees Fahrenheit (37 degrees Celsius).

Our mammalian ancestors had to find 10 times more food during their short waking time, and they had to find it in the dark of night. How did they accomplish this task?

To optimize their foraging, mammals developed a new system to efficiently memorize places where they’d found food: linking the part of the brain that records sensory aspects of the landscape – how a place looks or smells – to the part of the brain that controls navigation. They encoded features of the landscape in the neocortex, the outermost layer of the brain. They encoded navigation in the entorhinal cortex. And the whole system was interconnected by the brain structure called the hippocampus. Humans still use this memory system for remembering objects and past events, such as your car and where you parked it.

Groups of neurons in the neocortex encode these memories of objects and past events. Remembering a thing or an episode reactivates the same neurons that initially encoded it. All mammals likely can recall and re-experience previously encoded objects and events by reactivating these groups of neurons. This neocortex-hippocampus-based memory system that evolved 200 million years ago became the first key step toward imagination.

The next building block is the capability to construct a “memory” that hasn’t really happened.
Involuntary made-up ‘memories’

The simplest form of imagining new objects and scenes happens in dreams. These vivid, bizarre involuntary fantasies are associated in people with the rapid eye movement (REM) stage of sleep.

Scientists hypothesize that species whose rest includes periods of REM sleep also experience dreams. Marsupial and placental mammals do have REM sleep, but the egg-laying mammal the echidna does not, suggesting that this stage of the sleep cycle evolved after these evolutionary lines diverged 140 million years ago. In fact, recording from specialized neurons in the brain called place cells demonstrated that animals can “dream” of going places they’ve never visited before.

In humans, solutions found during dreaming can help solve problems. There are numerous examples of scientific and engineering solutions spontaneously visualized during sleep.

The neuroscientist Otto Loewi dreamed of an experiment that proved nerve impulses are transmitted chemically. He immediately went to his lab to perform the experiment – later receiving the Nobel Prize for this discovery.

Elias Howe, the inventor of the first sewing machine, claimed that the main innovation, placing the thread hole near the tip of the needle, came to him in a dream.

Dmitri Mendeleev described seeing in a dream “a table where all the elements fell into place as required. Awakening, I immediately wrote it down on a piece of paper.” And that was the periodic table.

These discoveries were enabled by the same mechanism of involuntary imagination first acquired by mammals 140 million years ago.

Imagining on purpose

The difference between voluntary imagination and involuntary imagination is analogous to the difference between voluntary muscle control and muscle spasm. Voluntary muscle control allows people to deliberately combine muscle movements. Spasm occurs spontaneously and cannot be controlled.

Similarly, voluntary imagination allows people to deliberately combine thoughts. When asked to mentally combine two identical right triangles along their long edges, or hypotenuses, you envision a square. When asked to mentally cut a round pizza by two perpendicular lines, you visualize four identical slices.

This deliberate, responsive and reliable capacity to combine and recombine mental objects is called prefrontal synthesis. It relies on the ability of the prefrontal cortex located at the very front of the brain to control the rest of the neocortex.

When did our species acquire the ability of prefrontal synthesis? Every artifact dated before 70,000 years ago could have been made by a creator who lacked this ability. On the other hand, starting about that time there are various archeological artifacts unambiguously indicating its presence: composite figurative objects, such as lion-man; bone needles with an eye; bows and arrows; musical instruments; constructed dwellings; adorned burials suggesting the beliefs in afterlife, and many more.

Multiple types of archaeological artifacts unambiguously associated with prefrontal synthesis appear simultaneously around 65,000 years ago in multiple geographical locations. This abrupt change in imagination has been characterized by historian Yuval Harari as the “cognitive revolution.” Notably, it approximately coincides with the largest Homo sapiens‘ migration out of Africa.

Genetic analyses suggest that a few individuals acquired this prefrontal synthesis ability and then spread their genes far and wide by eliminating other contemporaneous males with the use of an imagination-enabeled strategy and newly developed weapons.

So it’s been a journey of many millions of years of evolution for our species to become equipped with imagination. Most nonhuman mammals have potential for imagining what doesn’t exist or hasn’t happened involuntarily during REM sleep; only humans can voluntarily conjure new objects and events in our minds using prefrontal synthesis.

READ ORIGINAL STORY HERE

Africa Looks To Renewables To Curb Warming, Boost Economies

FILE - Workers install solar panels at a photovoltaic solar park situated on the outskirts of the coastal town of Lamberts Bay, South Africa on March. 29, 2016. Renewable energy's potential across the African continent remains largely untapped, according to a new report in April 2022 by the United Nation's Intergovernmental Panel on Climate Change. (AP Photo/Schalk van Zuydam, File)

BY WANJOHI KABUKURU

MOMBASA, KENYA (AP) — From wind farms across the African coastline to geothermal projects in the east African rift valley, a new United Nations climate report on Monday brought the continent’s vast clean energy potential into the spotlight. If realized, these renewable energy projects could blunt the harshest global warming effects, power the continent’s projected economic development and lift millions out of poverty, the report said.

The U.N.’s Intergovernmental Panel for Climate Change report comes at a time when Africa’s renewable energy business is already booming. Many African nations are intensifying efforts to embrace alternative renewable energy pathways and shift away from fossil fuel dependency, with countries such as Kenya, Tanzania, Morocco, Egypt, Ethiopia and South Africa taking the lead on large-scale clean energy adoption.

That means more renewable energy intiatives, such as Kenya’s Lake Turkana Wind Power, launched in 2019 some 600km (372 miles) northwest of the capital Nairobi and making up 18% of the country’s energy production, are needed. Its CEO, Phylip Leferink, said large projects like these can be replicated, but it remains logistically challenging.

“The wind conditions in the north of Kenya are rather unique for the continent. You will be hard-pressed to find another location in Africa with a similar wind regime,” Leferink said. “(This) however does not mean that there is no potential for other wind projects in Africa; there most certainly is. Especially the African coastline, from Djibouti all the way south around South Africa and up north again up to Cameroon, has good wind potential and certainly warrants initiatives in this regard.”

The project is already in good company, with off-grid solar power also contributing to the country’s energy production. In Nakuru county, some 167km (104 miles) northwest of Nairobi, James Kariuki signed up for M-Kopa solar power, a pay-as-you-go low-cost financing for off-grid solar power to his home.

“When I installed solar power into my home, I ended up making considerable savings from the use of kerosene lamp for lighting and charcoal in my house,” Kariuki said. “Hospital bills for my family have since gone down and we now have internet and watch international sports in my home.”

Since 2012, M-Kopa has powered over 225,000 homes in Kenya, Uganda and Tanzania with off-grid solar power. Kenya has also been expanding its geothermal and bioenergy capacity for several years.

These initiatives are a firm step in the right direction, according to report author and energy expert Yamina Saheb.

“Renewable energy sources are definitely an important mitigation strategy for Africa, offering its citizens decent living standards by developing infrastructure and buildings that do not require carbon intensive solutions,” Saheb told the Associated Press. “The whole continent could go solar including PV (photovoltaic) and thermal solar and some countries could also go for wind.”

Solar energy initiatives such as the Noor Ouarzazate complex in Morocco, Benban solar park in Egypt and South Africa’s Redstone solar park have sprung up across the continent. The four nations attracted 75% of all the renewable energy investments flows in the region.

Africa has a world-leading capacity for even more solar power initiatives, the report said, with a solar photovoltaic potential of up to 7900 gigawatts. Plans are also underway to explore the potential for geothermal energy in the east African rift valley system and nations dotted around the continent, such as Angola, Sudan and Zambia, are investing in wind and hydropower.

A transition to clean energy is also “economically attractive” in some circumstances, the IPCC report said. The U.N. estimates that Africa’s continued uptake of renewable energies will see the creation of more than 12 million new jobs. China remains the largest lender of Africa’s renewable energy investments followed by the African Development Bank, World Bank and the Green Climate Fund.

“This latest IPCC working group report on mitigation is a clear indicator that Africa should harness the immense renewable energies opportunities available within the continent to power economic growth and build resilient infrastructure,” said Max Bankole Jarrett, an energy expert and former Africa regional manager at the International Energy Agency. “Africa’s vast renewable energy sources should be a priority not just for the continent but also for the world racing to fulfill the net zero ambition.”

53 African nations have already submitted their voluntary national determined contributions under the Paris climate agreement which details energy plans and outlines targets to curb emissions. 40 of those countries have included renewable energy targets.

Africa suffers some of the most severe effects from climate change, despite being the lowest greenhouse gas emitting continent with the least adaptive capacity. Swathes of the continent still lack access to electricity and cooking fuels: The International Energy Agency estimates some 580 million people were without power in 2019, and the World Health Organization says about 906 million are in need of cleaner cooking fuels and technologies. But providing universal access using non-renewable energy sources would lead to increased global emissions, the report warned.

“Climate action is a key component in meeting the sustainable development goals,” it said.

Associated Press climate and environmental coverage receives support from several private foundations. See more about AP’s climate initiative here. The AP is solely responsible for all content.

Plant-Based Foods May Offer Reduced Risk for Aggressive Prostate Cancer

Science Daily (Oct. 19, 2012) — President George W. Bush made no secret that he detested broccoli. With all due respect to our former leader, researchers have found one more great reason to add fruits, vegetables, herbs and tea to your diet.

A study by Susan Steck of the Arnold School of Public Health finds that a high intake of flavonoids, a group of compounds found in plants, may lower the risk for highly aggressive prostate cancer.

"Incorporating more plant-based foods and beverages, such as fruits, vegetables, herbs and tea, into the diet may offer some protection against aggressive prostate cancer," said Steck, an associate professor at the Arnold School and an affiliated scholar with the Center for Research in Health Disparities.

"Filling your plate with flavonoid-rich foods is one behavior that can be changed to have a beneficial impact on health," she said.

Steck presented her findings at the International Conference on Frontiers in Cancer Prevention Research. The annual event is sponsored by the American Association for Cancer Research, whose mission is to prevent and cure cancer through research, education, communication and collaboration.

Prior preclinical studies have shown that flavonoids have beneficial effects against prostate cancer, but few studies have examined the effect of flavonoids on prostate cancer in humans.

Steck and her colleagues used data from 920 African-American men and 977 white men in the North Carolina-Louisiana Prostate Cancer Project who were newly diagnosed with prostate cancer. Participants completed a self-reported dietary history questionnaire to assess flavonoid intake, which was measured using the U.S. Department of Agriculture's 2011 Database for the Flavonoid Content of Selected Foods.

Men with the highest total intake of flavonoids had a 25 percent lower risk for aggressive prostate cancer compared with those men with the lowest flavonoid intake.

"We found that higher total flavonoid intake was associated with reduced odds for aggressive prostate cancer in both African-American and European-American men, but no individual subclass of flavonoids appeared to be protective independently, suggesting that it is important to consume a variety of plant-based foods in the diet, rather than to focus on one specific type of flavonoid or flavonoid-rich food," Steck said.

In addition, the risk for aggressive prostate cancer was even lower in those men younger than 65 and in current smokers with the highest levels of flavonoid intake. Dietary questionnaire results revealed that citrus fruits and juices, such as oranges and grapefruits, tea, grapes, strawberries, onions and cooked greens were the top contributors to total flavonoid intake among the participants. "The results support public health recommendations and guidelines from organizations such as the American Institute for Cancer Research to consume a more plant-based diet," Steck said. "In particular, consuming more flavonoid-rich foods may be beneficial for those people who are at increased risk for cancer, such as smokers."